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Anti-phospho-JAK2 (Tyr1007/1008) Antibody
| 产品编号： | 4090213 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-JAK2 (Tyr1007/1008) Antibody
Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Janus kinase 2 (JAK2) is a ubiquitous non-receptor tyrosine kinase that interacts with multiple cell-surface receptors and non-receptor proteins to affect a range of cellular processes including immunity, cell growth, development, and differentiation. Among JAK2’s receptor partners are the prolactin, growth hormone, thrombopoitin, and INF (α and β) receptors. JAK2 plays an important role in connecting the signaling pathways of these receptors to the activation of target genes. Upon ligand binding these receptors activate JAK2 inducing JAK2 autophosphorylation; This activated JAK2 in turn phosphorylates the cytoplasmic domains of these receptors providing a binding site for STAT transcription factors which are also phosphorylated by JAK2 leading to STAT protein dimerization and translocation to the nucleus to effect gene transcription. Aberrations in JAK2 expression and function may contribute to myelofibrosis and myelogenous leukemia. |
| Specificity【特异性】 | This antibody recognizes JAK2 phosphorylated at (Tyr1007/Tyr1008). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human JAK2 phosphorylated at (Tyr1007/Tyr1008). Epitope: Phosphorylated (Tyr1007/Tyr1008) |
| Application【应用】 | Research Category Signaling Anti-phospho-JAK2 (Tyr1007/1008) Antibody is an antibody against phospho-JAK2 (Tyr1007/1008) for use in WB. |
| Quality【质量】 | Evaluated by Western Blot in LPS/IFN gamma untreated and treated RAW264.7 cell lysates. Western Blot Analysis: A 1:5,000 dilution of this antibody detected JAK2 on 10 µg of LPS/IFN gamma untreated and treated RAW264.7 cell lysates. |
| Linkage【联系】 | Replaces: 04-1098 |
| Physical form【外形】 | Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control LPS/IFN gamma untreated and treated RAW264.7 cell lysates |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, pig |
| species reactivity (predicted by homology) | rat (based on 100% sequence homology), zebrafish (based on 100% sequence homology), Xenopus (based on 100% sequence homology), porcine (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_004963 |
| UniProt accession no.【UniProt登记号】 | O60674 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~130 kDa observed. Uncharacterized bands appear at ~48, 55, 65, and 100 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
