Sieber amide resin

400

Novabiochem^®

beads

reaction type: Fmoc solid-phase peptide synthesis

Novabiochem^®

peptide synthesis

amine

2-8℃

A hyper acid-labile linker for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage [1, 2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides [3].

This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4].

The product number for this product was previously 01-64-0059.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Replaces: 01-64-0059

Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH₂Cl₂): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

11 - Combustible Solids

WGK 1