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Anti-phospho-STAT3 (Tyr68) Antibody
| 产品编号： | 4088525 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μg |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-STAT3 (Tyr68) Antibody
Signal transducer and activator of transcription 3, Acute-phase response factor
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | This protein is a member of the family of STAT proteins (Signal Transduction and Activators of Transcription). These proteins are latent cytoplasmic transcription factors with the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. The Stat3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, onM, LIF, CNTF, G-CSF, IL-12, IL-2, GH, EGF, PDGF, and CSF-1. Stat3 is not activated by IFN beta. One active Stat3 translocates to the nucleus and binds to DNA as either a homodimer or as a heterodimer with Stat1. Transcription factors associated with Stat3 include cJun and cyclic AMP responsive enhancer binding protein (CREB). Stat3 interacts with the APRE (acute phase response element) and the SIE (c-sis inducible element). |
| Specificity【特异性】 | This antibody recognizes STAT3 phosphorylated at Tyr68. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human STAT3 phosphorylated at Tyr68. Epitope: Phosphorylated Tyr68 |
| Application【应用】 | Research Sub Category Transcription Factors Research Category Epigenetics & Nuclear Function Signaling Detect phospho-STAT3 (Tyr68) using this Anti-phospho-STAT3 (Tyr68) Antibody validated for use in WB. |
| Quality【质量】 | Evaluated by Western Blot in PMA treated and untreated MOLT4 cell lysates. Western Blot Analysis: 5 µg/mL of this antibody detected STAT3 on 10 µg of PMA treated and untreated MOLT4 cell lysates. |
| Physical form【外形】 | Antigen Affinity Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Analysis Note【分析说明】 | Control PMA treated and untreated MOLT4 cell lysates |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, pig |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology), Xenopus (based on 100% sequence homology), zebrafish (based on 100% sequence homology), porcine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003141 |
| UniProt accession no.【UniProt登记号】 | P40763 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... STAT3(6774) |
产品说明
| Target description【目标描述】 | ~75 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
