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Anti-Substance P Receptor Antibody, pain
产品别名
Anti-Substance P Receptor Antibody, pain
NK-1 receptor
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs. |
| Specificity【特异性】 | Specific for the Substance P Receptor (NK-1). |
| Immunogen【免疫原】 | Epitope: C terminus Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1). |
| Application【应用】 | Research Sub Category Neuroinflammation & Pain Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB. Immunohistochemistry: A previous lot was used at 1:100-1:1,000 dilution. Western Blot Analysis: A previous lot was used at 1:500 dilution. Optimal working dilutions must be determined by the end user. Research Category Neuroscience |
| Quality【质量】 | Evaluated by western blot on Mouse brain membrane lysates. Western Blot Analysis: 1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates. |
| Linkage【联系】 | Replaces: AB5800 |
| Physical form【外形】 | Unpurified Rabbit polyclonal serum containing no preservative. |
| Analysis Note【分析说明】 | Control Spinal Cord, brain membrane lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | serum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | mouse, rat, guinea pig |
| manufacturer/tradename | Chemicon® |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NM_003182.1 |
| UniProt accession no.【UniProt登记号】 | P20366 |
| shipped in【运输】 | dry ice |
| Gene Information | human ... TAC1(6863) |
产品说明
| Target description【目标描述】 | 35 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
