IL-1R Antagonist-CAS 566914-00-9-Calbiochem

C₁₈H₂₆N₂O₂

302.41

A cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
TIR domain-mediated MyD88/IL1-RI interaction

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

oil

Calbiochem^®

OK to freeze

colorless

DMSO: 10 mg/mL
ethanol: soluble

ambient

2-8℃

10, 25 mg in Plastic ampoule
Packaged under inert gas

10 - Combustible liquids

WGK 1