广州伟伯科技有限公司
您的位置:首页 > 产品中心 > RAR, β human
产品搜索:

RAR, β human

产品编号:4084923
规格:recombinant, expressed in E. coli, ≥75% (SDS-PAGE)
包装规格:5 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40849235 μG7220
产品别名

RAR, β human

NR1B2

HAp

RRB2

基本信息
NACRES
NA.26
Biochem/physiol Actions【生化/生理作用】
Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes ( α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. Retinoids, the natural and synthetic vitamin A derivatives, are known to inhibit the proliferation of lung cancer and breast cancer cells and the growth of carcinogen-induced bronchogenic squamous cell carcinoma and mammary tumors, and have been used as chemoprevention agents against both types of cancer. A growing body of evidence supports the hypotheses that the RAR beta gene is a tumor suppressor gene and the chemopreventive effects of retinoids are due to induction of RAR beta. RAR beta expression is reduced in many malignant tumors including breast carcinoma.
Physical form【外形】
Clear and colorless frozen liquid solution
Preparation Note【制备说明】
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥75% (SDS-PAGE)
form【形式】
frozen liquid
mol wt【分子量】
~52.5 kDa
packaging【包装】
pkg of 5 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
concentration【浓度】
250 μg/mL
color【颜色】
clear colorless
NCBI accession no.【NCBI登记号】
NM_000965
UniProt accession no.【UniProt登记号】
P10826
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... RARB(5915)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0079