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Diacylglycerol Kinase Inhibitor I-CAS 93076-89-2-Calbiochem
| 产品编号： | 4083829 |
| 规格： | The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 93076-89-2 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083829 | 5 MG | 2380 |
产品别名
93076-89-2
Diacylglycerol Kinase Inhibitor I-CAS 93076-89-2-Calbiochem
R59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one, R59022
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H26FN3OS |
| Molecular weight | 459.58 |
| MDL number | MFCD00055114 |
| General description【一般描述】 | Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC50 = 3.6 µM) and in isolated membranes (IC50 = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC50 = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin-S2 antagonist. Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Diacylglycerol Kinase Product does not compete with ATP. Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C. |
| Other Notes【其他说明】 | Goin, M., et al. 1993. FEBS Lett. 316, 68. Ohtsuka, T., et al. 1990. J. Biol. Chem.265, 15418. de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem.260, 15762. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | ethanol: 12 mg/mL DMSO: 4 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3 |
| InChI key | MFVJXLPANKSLLD-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
