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Dihydroorotate Dehydrogenase Inhibitor, Brequinar-CAS 96201-88-6-Calbiochem
产品编号: | 4083515 |
规格: | An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). |
CAS NO: | 96201-88-6 |
包装规格: | 10 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4083515 | 10 MG | 2640 |
产品别名
96201-88-6
Dihydroorotate Dehydrogenase Inhibitor, Brequinar-CAS 96201-88-6-Calbiochem
NSC 368390, DuP 785, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt
6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785
基本信息
Empirical Formula【经验(实验)分子式】 | C23H14F2NNaO2 |
Molecular weight | 397.35 |
General description【一般描述】 | A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM). |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target DHODH |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | He, T. et al. 2013. Oncogene32, in press. Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett.16, 1610. Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents.38, 435. Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett.14, 1549. Allison, A., et al. 1993. Transplantation Proc.25, 67. Cramer, D. et al. 1992. Transplantation.53, 303. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | solid |
potency【效能】 | 12 nM IC50 |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: 50 mg/mL |
storage temp.【储存温度】 | 2-8℃ |
InChI | 1S/C23H15F2NO2.Na/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;/h2-12H,1H3,(H,27,28);/q;+1/p-1 |
InChI key | PZOHOALJQOFNTB-UHFFFAOYSA-M |
packaging【包装】 | Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |