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Anti-Collagen Type III antibody, Mouse monoclonal
| 产品编号： | 4079709 |
| 规格： | clone FH-7A, purified from hybridoma cell culture |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Collagen Type III antibody, Mouse monoclonal
Anti-COL3A1
Anti-Collagen alpha-1(III) chain
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-collagen type III antibody, mouse monoclonal (mouse IgG1 isotype) is derived from the FH-7A hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c immunized mouse. Monoclonal anti-collagen type III specifically recognizes native and denatured collagen type III from human 1 and rat 2 origin. It does not recognize collagen types I, II, IV, V, VI and X. Collagen type III, also known as collagen α-1(III) (COL3A1), is encoded by the gene mapped to human chromosome 2q24.3-q31. It is the highly expressed collagen in blood vessels and hollow organs. |
| Immunogen【免疫原】 | Human Collagen Type III |
| Biochem/physiol Actions【生化/生理作用】 | Collagen a-1(III) (COL3A1) serves as a potent adjunct marker for both differentiating fibroadenoma (FA) from phyllodes tumor (PT) and measuring malignant potential in PTs. Overexpression of the gene in glomerular leads to the development of collagen type III glomerulopathy. Mutations in the gene is associated with the development of familial aortic aneurysms and Ehlers-Danlos syndrome. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
| Other Notes【其他说明】 | In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | FH-7A, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~70 kDa |
| species reactivity | human, rat |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | ELISA: suitable immunoblotting: suitable immunofluorescence: suitable immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat skin sections. |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P02461 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... COL3A1(1281) |
产品说明
| Storage and Stability【储存及稳定性】 | Store at -20℃. For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
