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Lomefloxacin Hydrochloride

产品编号:4076464
CAS NO:98079-52-8
包装规格:1 G,10 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40764641 G523
407646410 G2880
产品别名

98079-52-8

Lomefloxacin Hydrochloride

1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C17H19F2N3O3 · HCl
Molecular weight
387.81
MDL number
MFCD00214312
PubChem Substance ID【PubChem化学物质编号】
24278514
NACRES
NA.85
General description【一般描述】
Chemical structure: fluoroquinolone
Application【应用】
Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice and modification of the kinetics of growth of Gram-negative bacteria.
Biochem/physiol Actions【生化/生理作用】
Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
synthetic
color【颜色】
white to off-white
Mode of action【作用机制】
DNA synthesis | interferes
enzyme | inhibits
antibiotic activity spectrum【抗生素抗菌谱】
Gram-negative bacteria
Gram-positive bacteria
storage temp.【储存温度】
−20℃
SMILES string
Cl.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12
InChI
1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
InChI key
KXEBLAPZMOQCKO-UHFFFAOYSA-N
packaging【包装】
1, 10 g in poly bottle
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302
Hazard Classifications【危险分类】
Acute Tox. 4 Oral
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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