Bisindolylmaleimide I, Hydrochloride-CAS 176504-36-2-Calbiochem

C₂₅H₂₄N₄O₂ · xHCl

412.48 (free base basis)

MFCD00236429

A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). Inhibits protein kinase A at much higher concentrations (K_i = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). May inhibit protein kinase A at much higher concentrations (K_i = 2 µM).

Target K_i: 10 nM against protein kinase C
Primary Target
Protein kinase C
Product competes with ATP.
Cell permeable: no
Reversible: yes

Toxicity: Standard Handling (A)

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze

orange-red

water: 10 mg/mL
DMSO: 20 mg/mL

ambient

2-8℃

1 mg in Plastic ampoule
250 μg in Plastic ampoule

11 - Combustible Solids

WGK 3