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Caspase-3 Inhibitor II-CAS 210344-95-9-Calbiochem
| 产品编号： | 4075240 |
| 规格： | The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. |
| CAS NO： | 210344-95-9 |
| 包装规格： | 250 μG，1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
210344-95-9
Caspase-3 Inhibitor II-CAS 210344-95-9-Calbiochem
Z-D(OMe)E(Ome)VD(OMe)-FMK
基本信息
| Empirical Formula【经验(实验)分子式】 | C30H41FN4O12 |
| Molecular weight | 668.66 |
| General description【一般描述】 | A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available. A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target caspase-3, caspase-6, caspase-7, caspase-8, caspase-10 |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥90% (TLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated |
| color【颜色】 | white to slightly brown |
| solubility【溶解性】 | DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule 250 μg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
