IKK Inhibitor VII-CAS 873225-46-8-Calbiochem

C₂₈H₂₉N₅OS

483.63

A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC₅₀ = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC₅₀ = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 505378).

Cell permeable: yes
Reversible: no
Target IC₅₀: 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively
Product competes with ATP.
Primary Target
IKK

Toxicity: Harmful (C)

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

pale yellow

DMSO: 10 mg/mL

wet ice

−20℃

1 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3