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Hsp25 Kinase Inhibitor-Calbiochem
| 产品编号： | 4061844 |
| 规格： | The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Hsp25 Kinase Inhibitor-Calbiochem
MK2 Inhibitor, KKKALNRQLGVAA, MAPKAP Kinase-2 Inhibitor
KKKALNRQLGVAA, MK2 Inhibitor, MAPKAP Kinase-2 Inhibitor
基本信息
| Empirical Formula【经验(实验)分子式】 | C61H113N21O16 |
| Molecular weight | 1396.68 |
| General description【一般描述】 | A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).] A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [also called mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Target Ki: 8.1 µM against (Hsp25) kinase Product does not compete with ATP. Cell permeable: yes Primary Target (Hsp25) kinase Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C. |
| Other Notes【其他说明】 | Katsoulidis, E., et al. 2005. Cancer Res.65, 9029. Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: soluble water: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
