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阿塞那平马来酸盐
Asenapine maleate
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3410382 | 10 MG | 1141 | |||
| 3410382 | 50 MG | 3150 |
产品别名
85650-56-2
阿塞那平马来酸盐
Asenapine maleate
(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12btetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate
Org 5222
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H16ClNO ·C4H4O4 |
| Molecular weight | 401.84 |
| EC number【EC 号】 | 288-064-8 |
| PubChem Substance ID【PubChem化学物质编号】 | 329770943 |
| NACRES | NA.77 |
| General description【一般描述】 | Asenapine maleate acts as an antimanic. It belongs to the family of dibenzoxepinopyrrolidines. Asenapine is considered to be a weak inhibitor of cytochrome P450 2D6 (CYP2D6). It increases the level of dopamine, norepinephrine and acetylcholine in brain. |
| Application【应用】 | Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models. Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania. |
| Biochem/physiol Actions【生化/生理作用】 | Asenapine maleate is a 5-HT receptor antagonist (5-HT1A,1B, 5-HT2A, 2B, 2C, 5-HT5A, 5-HT6 and 5-HT7), a D2 antagonist, and an antipsychotic. |
| Features and Benefits【特点和优势】 | This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | H2O: ≥10 mg/mL |
| originator【创始人】 | Merck & Co., Inc., Kenilworth, NJ, U.S. |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC(=O)\C=C/C(O)=O.CN1C[C@H]2[C@H](C1)c3cc(Cl)ccc3Oc4ccccc24 |
| InChI | 1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1 |
| InChI key | GMDCDXMAFMEDAG-CHHFXETESA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS09 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H315 - H319 - H335 - H400 |
| Precautionary Statements | P273 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
