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ARL-17477 dihydrochloride hydrate
产品别名
866914-87-6
ARL-17477 dihydrochloride hydrate
N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H20ClN3S·2HCl · xH2O |
| Molecular weight | 442.83 (anhydrous basis) |
| MDL number | MFCD21608518 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825207 |
| Application【应用】 | ARL-17477 dihydrochloride hydrate may be used in cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | ARL-17477 is an nNOS specific inhibitor. The IC50 against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury. |
| Features and Benefits【特点和优势】 | This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: ≥5 mg/mL |
| originator【创始人】 | AstraZeneca |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1 |
| InChI | 1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2 |
| InChI key | QOPATWWWZNTSQF-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H319 |
| Precautionary Statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
