Anti-ZNF461 antibody produced in rabbit

HPA021139    Human Protein Atlas characterization data

The gene ZNF461 (zinc finger protein 461) is mapped to human chromosome 19q13.1. It is widely expressed in human tissues. The protein contains a KRAB (kruppel associated box) A+B box and C2H2 type zinc finger motifs.

zinc finger protein 461 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

ZNF461 (zinc finger protein 461) is suggested to have transcriptional repression activity. In mouse testicular Leydig cell lines, NUR77 (nuclear hormone receptor) induces the expression of ZNF461. ZNF461 interacts with HDAC2 (histone deacetylase 2) and behaves as a corepressor of the orphan nuclear receptor steroidogenic factor 1 (SF-1). In rats, ZNF461 is induced by gonadotropin treatment.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST73792.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

Prestige Antibodies^® Powered by Atlas Antibodies

buffered aqueous glycerol solution

human

antibody small pack of 25 μL

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

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Q8TAF7

wet ice

−20℃

human ... ZNF461(92283)

10 - Combustible liquids

WGK 1