Anti-TTP (C-terminal) antibody produced in rabbit

NA.41

TTP is also known as Tristetraproline, Zfp-36, TIS11A, and Growth factor-inducible nuclear protein NUP475. TTP belongs to a family of human ARE (AU-rich element found in 3′ UTR mRNA) binding protein that contains tandem CCCH zinc finger RNA-binding domains required for interaction with ARE. TTP is a phosphoprotein. Anti-TTP (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human TTP conjugated to KLH.

synthetic peptide corresponding to amino acids 270-284 of human TTP conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.

Anti-TTP (C-terminal) antibody has been used in immunoprecipitationand may be used for immunoblotting.

Tristetraprolin (TTP) is an RNA-binding protein that suppresses inflammation by accelerating the degradation of cytokine mRNA. TTP plays a role in both mRNA deadenylation and 3′ to 5′ degradation of the mRNA and helps in recruiting several factors involved in these processes. TTP acts as a substrate for multiple kinases like ERK (extracellular signal-regulated kinases), JNK (Jun N-terminal kinase) , p38, and MAPKAPK2.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~50 kDa

human

~1.0 mg/mL

western blot: 0.5-1.0 μg/mL using lysates of HEK-293 cells overexpressing human TTP

P26651

dry ice

−20℃

human ... ZFP36(7538)
mouse ... Zfp36(22695)
rat ... Zfp36(79426)

TTP (C-terminal) (also known as Tristetraproline, Zfp-36, TIS11A, and Growth factor-inducible nuclear protein NUP475) is an RNA-binding protein that suppresses inflammation by accelerating the degradation of cytokine mRNA.

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