Anti-SPINK6 antibody produced in rabbit

HPA011039    Human Protein Atlas characterization data

SPINK6 (serine peptidase inhibitor, Kazal type 6) is an inhibitor of Kallikrein-related peptidases (KLKs) in skin. It contains one Kazal domain and its expression is induced during differentiation of keratinocytes. It is expressed in human skin in the stratum granulosum, as well as in sweat and sebaceous glands. It is expressed in skin of the complete human body. This gene is located on human chromosome 5q32.

serine peptidase inhibitor, Kazal type 6 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

SPINK6 (serine peptidase inhibitor, Kazal type 6) regulates the function of Kallikrein-related peptidases (KLKs) in skin, which in turn are involved in skin desquamation. In ex vivo studies, this protein prevents human plantar callus desquamation. It is down-regulated in atopic dermatitis lesions. It has an inhibitory function in human epidermis and keratinocytes, where it prevents the cleavage of substrates such as fibronectin, by KLKs. It also modulates the activity of proteases in human epidermis. It might be involved in regulating skin barrier function, as its expression is decreased after skin barrier injury.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72279.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

Prestige Antibodies^® Powered by Atlas Antibodies

buffered aqueous glycerol solution

human

antibody small pack of 25 μL

immunohistochemistry: 1:20- 1:50

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Q6UWN8

wet ice

−20℃

human ... SPINK6(404203)

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