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Anti-SMAD6 (AB1) antibody produced in rabbit
产品别名
Anti-SMAD6 (AB1) antibody produced in rabbit
Anti-SMAD family member 6
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The members of Smad protein family mediate the signal transduction of TGF-β. Signaling via Smad/TGF-β have been implicated in development, homeostasis and cancer development. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the N terminal region of human SMAD6 |
| Application【应用】 | Anti-SMAD6 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | Smad6 is an inhibitory Smad member that antagonizes the effects of TGF-β and BMP signaling. The mechanism of inhibition involves competing with receptor-regulated Smads. Smad6 inhibits the non-canonical pathway of TGF-β, regulating the activation of p38 MAPK/JNK. |
| Sequence【序列】 | Synthetic peptide located within the following region: GAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKE |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 53 kDa |
| species reactivity | human |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001136333 |
| UniProt accession no.【UniProt登记号】 | O43541 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SMAD6(4091) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
