Anti-RWDD3 antibody produced in rabbit

NA.41

RWDD3 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human RWDD3.

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

The action of this antibody can be blocked using blocking peptide SBP3500104.

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

mouse, rat, human

indirect ELISA: suitable
western blot: suitable

NP_056300

Q9Y3V2

dry ice

−20℃

human ... RWDD3(25950)

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

12 - Non Combustible Liquids

WGK 2