Anti-PMP22 antibody produced in rabbit

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous glycerol solution

17 kDa

rat, human, mouse

~1 mg/mL

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Q01453

Q01453

wet ice

−20℃

human ... PMP22(5376)

Peripheral myelin protein 22 (PMP22), also called as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein, encoded by the gene mapped to human chromosome 17p12–13. PMP22 is highly expressed in myelin-forming Schwann cells of peripheral nerves.
Anti-PMP22 Antibody detects endogenous levels of total PMP22 protein.

The antiserum was produced against synthesized peptide derived from human PMP22.

Immunogen Range: 111-160

Anti-PMP22 antibody produced in rabbit has been used in:

• immunofluorescence
• western blotting
• immunohistochemistry

Anti-PMP22, C-Terminal antibody produced in rabbit has been used in immunofluorescence analysis.

Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during development of peripheral nerve, cell–cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Biological function of PMP22, might include formation and or maintenance of intercellular junctions and possibly of tight junctions (TJs). Aberrations, duplications or mutations in PMP22 gene lead to majority of heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. PMP2, might be involved in regulation of Schwann cell proliferation and differentiation.5 Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML). PMP22 might, thus, act as a therapeutic target for the treatment of CML.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

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