Anti-PMP22 antibody produced in rabbit

NA.41

PMP22 (peripheral myelin protein-22) is a tetraspan integral membrane protein, that contains four putative transmembrane domains. It is expressed in the peripheral nervous system. PMP22 is produced by myelinating Schwann cells. It is an important constituent of peripheral myelin. This gene is mapped to human chromosome 17p11.2.

Anti-PMP22 recognizes human PMP22.

synthetic peptide corresponding to amino acid residues 118-133 of human PMP22, with an added cysteine, conjugated to KLH. The corresponding sequence differs by 3 amino acids in rat and mouse.

PMP22 (peripheral myelin protein-22) participates in the progression of CNS (central nervous system) myelin. It modulates self-renewal and chemoresistance of gastric cancer cells. Mutation in PMP22 results in Charcot-Marie tooth disease.
PMP22 plays a role in peripheral nerve myelin formation, cell-cell interactions, and cell proliferation. Overexpression of PMP22 is implicated in the neoplastic transformation of normal tissue to pre-malignant lesions and cancer of the pancreas and osteoblasts.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~22 kDa

human

~1.0 mg/mL

immunohistochemistry: 2.5-5 μg/mL using biotin/ExtrAvidin^™-Peroxidase staining of formalin-fixed, paraffin-embedded human spinal cord sections

Q01453

dry ice

−20℃

human ... PMP22(5376)
mouse ... Pmp22(18858)
rat ... Pmp22(24660)

For continuous use, store at 2-8 ℃ for up to one month. For extended storage, freeze at -20 ℃ in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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