您的位置：首页 > 产品中心 > Anti-PI4KCA (C-term) antibody produced in rabbit
Anti-PI4KCA (C-term) antibody produced in rabbit
| 产品编号： | 3386106 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PI4KCA (C-term) antibody produced in rabbit
Anti-PI4K-α
Anti-PI4-kinase
Anti-PtdIns-4-kinase
Anti-Phosphatidylinositol 4-kinase α
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene. Variant 1 is alternatively spliced at the 5′ end compared to transcript variant 2. However, it maintains the same reading frame and encodes an isoform 1 (97 kDa) which is truncated at the N-terminus compared to isoform 2 (230 kDa). Isoform 1 has enzymatic properties characteristic of type II PI 4-kinases. Variant 2 is full-length, and encodes the longer isoform 2 with a different N-terminus compared to isoform 1. Isoform 2 has enzymatic properties characteristic of type III PI 4-kinases. |
| Immunogen【免疫原】 | PI4KCA (2019-2054) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PI4KCA. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 |
| NCBI accession no.【NCBI登记号】 | NP_002641 |
| UniProt accession no.【UniProt登记号】 | P42356 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PI4KCA(5297) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
