Anti-phospho-RB1 (pSer⁷⁹⁵) antibody produced in rabbit

MFCD00282455

Retinoblastoma transcriptional corepressor 1 (RB1) is encoded by the gene mapped to human chromosome 13q14.2.

Peptide sequence around phosphorylation site of serine 795 (P-S-S(p)-P-L), according to the protein RB1.

Retinoblastoma transcriptional corepressor 1 (RB1) is a tumor suppressor which modulates the cell cycle. It acts as a repressor of transcription mediated by E2 factor (E2F) and influences transcriptional silencing. RB1 modulates mitochondrial activities and has a role in the organization of heterochromatin. Polymorphism in the gene leads to the development of childhood retinoblastoma.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~110 kDa

human

1 mg/mL

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

IgG

(P-S-SP-P-L)

NP_000312.2

P06400

wet ice

−20℃

human ... RB1(5925)

Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

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10 - Combustible liquids

WGK 1