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Anti-phospho-NF-κB p100 (pSer872) antibody produced in rabbit
产品别名
Anti-phospho-NF-κB p100 (pSer872) antibody produced in rabbit
Lyt10
Nuclear factor NF-kappa-B p100 subunit
DNA-binding factor KBF2
Oncogene Lyt-10
Lymphocyte translocation chromosome 10
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Nuclear factor kappa B subunit 2 (NFKB2) encodes the nuclear factor kappa B2 (NF-κB), a nuclear transcription factor. NF-κB is evolutionarily highly conserved. In human chromosome, the gene NFKB2 is localized on 10q24. |
| Specificity【特异性】 | The antibody detects endogenous level of NF-κB p100 only when phosphorylated at serine 872. |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of serine872(S-Q-S(p)-V-E) derived from Human NF-κB p100 . |
| Biochem/physiol Actions【生化/生理作用】 | Regulation of nuclear factor kappa B subunit 2 (NFKB2) includes cytoplasmic-nuclear shuttling and its transcriptional activity. NF-κB plays a key role in regulating the immune response and apoptotic processes. It is necessary for combating diseases like arthritis, autoimmune diseases and asthma. Mutations in NFKB2 impairs post translational processing of p100 preventing nuclear translocation of p52. This leads to common variable immunodeficiency and adrenal insufficiency. Mutation also affects canonical and non-canonical pathway of NFKB2 signalling and causes autosomal dominant primary antibody deficiency (PAD). chromosomal aberrations in C-terminal region of NFKB2 is associated lymphoid malignancies. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 100 kDa |
| species reactivity | mouse, human, rat |
| concentration【浓度】 | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| isotype【同位素/亚型】 | IgG |
| accession no.【登记号】 | NP_001070962.1 |
| UniProt accession no.【UniProt登记号】 | Q00653 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... NFKB2(4791) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
