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Anti-phospho-Met (pTyr1349) antibody produced in rabbit
产品别名
Anti-phospho-Met (pTyr1349) antibody produced in rabbit
Anti-c-Met antibody produced in rabbit
Anti-HGFR antibody produced in rabbit
Anti-RCCP2 antibody produced in rabbit
Anti-met proto-oncogene (hepatocyte growth factor receptor) antibody produced in rabbit
Anti-AUTS9 antibody produced in rabbit
基本信息
| MDL number | MFCD01633070 |
| NACRES | NA.41 |
| General description【一般描述】 | Mesenchymal epithelial transition (MET) is a proto oncogene, mapped to human chromosome 7q21–q31. The encode protein is a transmembrane receptor tyrosine kinase (RTK) and is activated by an endogenous ligand, scatter factor or hepatocyte growth factor (HGF). |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of tyrosine 1349 (E-H-Y(p)-V-H), according to the protein MET. |
| Biochem/physiol Actions【生化/生理作用】 | Mesenchymal epithelial transition (MET) facilitates wound healing and hepatic regeneration, with vital roles in embryonic, neuronal and muscle development.Mutations in the gene leads to non-small cell lung cancer (NSCLC). Copy number (GCN) of c-MET acts as a potential marker to determine poor prognosis in ovarian carcinoma patients. Binding of hepatocyte growth factor (HGF) to MET activates downstream signaling of various pathway, including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B), signal transducer and activator of transcription proteins, and nuclear factor-κB. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~156 kDa |
| species reactivity | human, mouse, rat |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (E-H-YP-V-H) |
| NCBI accession no.【NCBI登记号】 | NP_000236.2 |
| UniProt accession no.【UniProt登记号】 | P08581 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MET(4233) |
产品说明
| Target description【目标描述】 | Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
