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Anti-phospho-GATA1 (pSer310) antibody produced in rabbit
产品别名
Anti-phospho-GATA1 (pSer310) antibody produced in rabbit
Anti-NFE1 antibody produced in rabbit
Anti-ERYF1 antibody produced in rabbit
Anti-GF-1 antibody produced in rabbit
Anti-GATA binding protein 1 (globin transcription factor 1) antibody produced in rabbit
Anti-GF1 antibody produced in rabbit
基本信息
| MDL number | MFCD02096392 |
| NACRES | NA.41 |
| General description【一般描述】 | GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is encoded by the gene mapped to human chromosome Xp11.23 and it belongs to the GATA transcription factor family. |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of serine 310 (K-A-S(p)-G-K), according to the protein GATA1. |
| Biochem/physiol Actions【生化/生理作用】 | GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~43 kDa |
| species reactivity | human, rat, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (K-A-SP-G-K) |
| NCBI accession no.【NCBI登记号】 | NP_002040.1 |
| UniProt accession no.【UniProt登记号】 | P15976 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GATA1(2623) |
产品说明
| Target description【目标描述】 | GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
