您的位置：首页 > 产品中心 > Anti-phospho-Aurora Kinase (pThr288) antibody produced in rabbit
Anti-phospho-Aurora Kinase (pThr288) antibody produced in rabbit
产品别名
Anti-phospho-Aurora Kinase (pThr288) antibody produced in rabbit
STK-6
Aurora 2
BTAK
Aurora A
STK15
ARK1
AIK
HsAIRK1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Aurora kinase A (AURKA) belongs to the serine/threonine kinase family. It is localized to centrosomes. AURKA gene is located on human chromosome 20q13.2. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human Aurora Kinase around the phosphorylation site of Thr288. Immunogen Range: 256-305 |
| Application【应用】 | Anti-phospho-Aurora Kinase (pThr288) antibody produced in rabbit has been used in immunofluorescence staining. |
| Biochem/physiol Actions【生化/生理作用】 | Aurora kinase A (AURKA) is involved in maintaining the stability of mitosis and chromosomes. During mitosis, AURKA participates in centrosome maturation control, mitotic entry, bipolar spindle formation, and segregation. AURKA also participates in chromosome alignment and cytokinesis. It controls several oncogenic signaling pathways. AURKA plays a major role in the self-renewal, reprogramming, and differentiation of stem cells. Knockdown of AURKA gene affects the maturation of the centrosome. Abnormality in the AURKA gene leads to aberrant cell division and aneuploidy, which in turn affects the stability of the genome and contributes to carcinogenesis. Overexpression of the AURKA gene is seen in gastrointestinal, pancreatic, and liver cancers. It can act as a candidate gene to predict colorectal adenocarcinoma. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 45 kDa |
| species reactivity | human, rat, mouse |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | O14965 |
| UniProt accession no.【UniProt登记号】 | O14965 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... AURKA(6790) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
