Anti-PELP1 antibody produced in rabbit

NA.41

Proline, glutamate and leucine rich protein 1 (PELP1), also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a scaffold protein, encoded by the gene mapped to human chromosome 17p13.2. The encoded protein is composed of 1130 amino acids and is ubiquitously expressed, but at high levels in the brain, testes, ovaries and uterus. PELP1 is characterized with ten nuclear receptor (NR)-interacting boxes (LXXLL motifs), a zinc finger, a glutamic acid-rich domain and two proline-rich domains.

The immunogen for anti-PELP1 antibody: synthetic peptide derected towards the C terminal of human PELP1

The proto-oncogene proline, glutamate and leucine rich protein 1 (PELP1) plays a vital role in cancer progression by stimulating several pathways such as cell cycle, ribosome biogenesis, chromatin modifications, DNA damage response, histone methylation and RNA splicing. It acts as a coactivator for several transcription factors, such as estrogen receptor (ESR), ESR2, androgen receptor (AR), E2 factor and signal transducer and activator of transcription 3 (STAT3). PELP1 expression has been observed in various types of human cancers including breast, endometrial, ovarian, salivary, prostate, lung, pancreas and colon.

Synthetic peptide located within the following region: APSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVI

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

120 kDa

horse, rat, rabbit, dog, human, mouse, guinea pig

0.5 mg - 1 mg/mL

western blot: suitable

NM_014389

Q8IZL8

wet ice

−20℃

human ... PELP1(27043)

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12 - Non Combustible Liquids

WGK 3