Anti-Neuroglobin antibody produced in rabbit

MFCD09265363

Neuroglobin is an oxygen-binding heme protein predominantly expressed in the nervous system in man and other vertebrates. Neuroglobin belongs to the globin superfamily. It displays the typical globin fold, but it shares little amino acid sequence similarity with vertebrate hemoglobins and myoglobins. Neuroglobin is highly conserved among vertebrates and is evolutionary related to the invertebrate nerve globins. In mouse and rat, neuroglobin is preferentially expressed in neuronal cells of the central and peripheral nervous systems, but also in some endocrine tissues. Neuroglobin is highly expressed in neurons of mammalian retina.

synthetic peptide corresponding to amino acids 55-70 of human neuroglobin, conjugated to KLH.

Anti-Neuroglobin antibody produced in rabbit has been used in

• immunofluorescence double staining
• immunostaining
• immunohistochemistry

Neuroglobin may play an essential role in oxygen homeostasis of neuronal cells. Neuroglobin is thought to protect neurons from hypoxic-ischemic injury as suggested by its increased expression under hypoxic conditions in- vitro as well as in focal cerebral ischemia in vivo. Neuronal survival after hypoxia decreased when neuroglobin expression is inhibited by antisense oligonucleotide and enhanced by neuroglobin overexpression. Its distribution correlates with the subcellular localization of mitochondria and with oxygen demands, possibly linking neuroglobin to cellular respiration.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

ExtrAvidin is a registered trademark of sigma-aldrich Co. LLC

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

rat, human, mouse

~1.2 mg/mL

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2.5-5.0 μg/mL using biotin/ExtrAvidin^®-Peroxidase staining of heat-retrieved rat brain sections
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5.0-10.0 μg/mL using biotin/ExtrAvidin^®-Peroxidase staining of heat-retrieved human and mouse brain sections

Q9NPG2

dry ice

−20℃

human ... NGB(58157)

Neuroglobin is an oxygen-binding heme proteinpredominantly expressed in the nervous system.

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10 - Combustible liquids

WGK 3

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