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Anti-MUC1 antibody produced in rabbit
产品别名
Anti-MUC1 antibody produced in rabbit
Episialin
EMA
Carcinoma-associated mucin
CD227
Breast carcinoma-associated antigen DF3
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-MUC1 Antibody detects endogenous levels of total MUC1 protein. MUC1 (Mucin 1) is O-glycosylated, carbohydrate rich, transmembrane glycoprotein. It has approximately 13 members in the family. It is localized on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It is overexpressed in several epithelial cancers, including pancreatic ductal adenocarcinoma. It is a heterodimer consisting of N-terminal (MUC1-N) and C-terminal (MUC1-C) subunits. N-terminal (MUC1-N) end contains tandem repeats (VNTR) which forms the mucin component. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human MUC1. Immunogen Range: 1191-1240 |
| Application【应用】 | Anti-MUC1, C-Terminal antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence. |
| Biochem/physiol Actions【生化/生理作用】 | MUC1 (Mucin 1) plays a major role in the formation of epithelium lining of the gastrointestinal tract. It lubricates the gastrointestinal tract, to protect the epithelia from oesophagus to the colon. It also lubricates the epithelia of some organs such as pancreas and gall bladder. It is directly involved in several signaling pathways as a modulator that affects oncogenesis, motility and metastasis. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 122 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 |
| NCBI accession no.【NCBI登记号】 | P15941 |
| UniProt accession no.【UniProt登记号】 | P15941 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MUC1(4582) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
