Anti-MTMR4 (C-term) antibody produced in rabbit

rabbit

200

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

mouse, human

indirect ELISA: 1:1000
western blot: 1:100-1:500

NM_004687

Q9NYA4

dry ice

−20℃

human ... MTMR4(9110)

Myotubularin related protein 4 (MTMR), a member of the myotubularin family, alternatively known as FYVE (Fab1p, YO1B, Vac1p and EEA1) domain-containing dual specificity protein phosphatase 2 (FYVE-DSP2), encodes an intracellular protein of 1,195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. MTMR4 resides predominantly in the endosomal structures. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. In human chromosome, the gene MTMR4 is localized on 17q22-q23.

MTMR4 (NM_004687, 1159-1197)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MTMR4.

Myotubularin related protein 4 (MTMR4) dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate. MTMR4 plays a major role in vesicular trafficking and signal transduction. MTMR4 also dephosphorylates receptor-regulated small mothers against decapentaplegic homolog (R-Smads) and maintains transforming growth factor-beta (TGF-β) levels and thereby regulates its signalling pathway. MTMR4 interaction with Nedd4 (neural-precursor-cell- expressed developmentally down-regulated 4) leads to progression of skeletal muscle atrophy.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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12 - Non Combustible Liquids

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