Anti-MCM4 (AB1) antibody produced in rabbit

NA.41

MCM4 is a component of the mini-chromosome maintenance (MCM) complex. This complex is critical for the formation of the pre-replication complex required for replication initiation. The complex functions as a DNA helicase. MCM4 is found expressed in the nucleus with a molecular weight of 96 kDa.

Synthetic peptide directed towards the middle region of human MCM4

The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. The MCM4 gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks.

Synthetic peptide located within the following region: VYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYE

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

95 kDa

mouse, bovine, dog, guinea pig, horse, human, rat, rabbit

0.5 mg - 1 mg/mL

immunohistochemistry: suitable
western blot: suitable

NP_877423

P33991

wet ice

−20℃

human ... MCM4(4173)

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12 - Non Combustible Liquids

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