Anti-KIAA1706 antibody produced in mouse

NA.41

KIAA1706 is also known as endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1). The gene is located on human chromosome 7p14.2. This gene contains two helix−hairpin−helix motifs at the N-terminal and an exonuclease/endonuclease/phosphatase domain at the C-terminal end. The protein is localized in the plasma membrane with a myristoylation site in its N terminus.

KIAA1706 (AAH65518.1, 1 a.a. ~ 569 a.a) full-length human protein.

Sequence
MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLLAEQQPHHLATAVPLTPRVNINTATPAQLMSVRGLSEKMALSIVDFRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQPTLPNIRKWKGPRGCWKAVVAEKPSNQLQKGAGYAGFLWDAAAGMELRDAGSQESSPSNGHGKLAGPSPYLGRFKVGSHDLTLVNLHLAALTLLGSENPSKNHSDGHRLASFAQTLQETLKGEKDVIILGDFGQGPDSNDYDILRKEKFHHLIPAHTFTNISTKNPQGSKSLDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWSKKDAPRNGSGVALERSEANIKHER

Endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1), also known as KIAA1706, acts as a gatekeeper for the repair of stressed replication forks. It maintains the integrity of cell genome by developing safe homologous recombination fork repair pathway. Deficiency of this protein is associated with severe chromosomal abnormalities. The protein acts as a LXR-target gene, which maintains cholesterol efflux and activity of ATP-binding cassette transporter (ABCA1).

Solution in phosphate buffered saline, pH 7.4

100

mouse

unconjugated

purified immunoglobulin

primary antibodies

polyclonal

buffered aqueous solution

antigen ~62.4 kDa

human

western blot: 1 μg/mL

BC065518

Q7L9B9

dry ice

−20℃

human ... EEPD1(80820)

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13 - Non Combustible Solids

WGK 1