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Anti-Interleukin-1β antibody produced in goat

产品编号:3370099
规格:IgG fraction of antiserum
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
33700991 MG6520
产品别名

Anti-Interleukin-1β antibody produced in goat

Anti-IL-1β

基本信息
MDL number
MFCD00240949
NACRES
NA.41
General description【一般描述】
Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. IL-1β has pleiotrophic activities and is protective against infections by recruitment of neutrophils to the infection site, secretion of cytokines and chemokines and activation of adhesion molecules. IL-1β overproduction has been implicated in many auto-immune and allergic disorders such as Cryopirin-associated periodic syndromes, Muckle-Wells syndrome and skin lesions
Anti-Interleukin-1β antibody specifically reacts with mouse IL-1β. The antibody shows 25% cross reactivity with human recombinant IL-1β.
Specificity【特异性】
The antibody will neutralize the biological activity of recombinant mouse IL-1β, but not recombinant human IL-1β. The antibody shows ~25% cross-reactivity with recombinant human IL-1β.
Immunogen【免疫原】
recombinant mouse IL-1β.
Application【应用】
Anti-interleukin-1β may be used to neutralize the biological activity of recombinant mouse IL-1β on mouse T-helper D10.G4.1 cell line at a concentration of 50 picog/ml. No neutralization of the biological activity of recombinant human IL-1β is observed. The antibody may be used for immunoblotting at a working concentration 1-2 μg/ml or a dilution of 1:1000. In immunoblotting applications the antibody shows 25% cross-reactivity with human recombinant IL-1β.
Physical form【外形】
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Preparation Note【制备说明】
Purified using protein G.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
goat
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
IgG fraction of antiserum
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
mouse
technique(s)
neutralization: suitable
western blot: suitable
UniProt accession no.【UniProt登记号】
P10749
storage temp.【储存温度】
−20℃
Gene Information
mouse ... Il1b(16176)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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