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抗-白介素-10 山羊抗
Anti-Interleukin-10 antibody produced in goat
| 产品编号： | 3370074 |
| 规格： | IgG fraction of antiserum, lyophilized powder |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
抗-白介素-10 山羊抗
Anti-Interleukin-10 antibody produced in goat
Anti-IL-10
基本信息
| EC number【EC 号】 | 202-739-6 |
| MDL number | MFCD00241897 |
| NACRES | NA.41 |
| General description【一般描述】 | Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. The production of IL-10 is mediated by signalling of IL-6, IL-12 and TGF-β. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10 is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10 production is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis Anti-interleukin-10 antibody is specific for mouse IL-10. The antibody shows less than 5% cross reactivity to recombinant human IL-10. |
| Specificity【特异性】 | The antibody neutralizes the biological activity of recombinant mouse IL-10. |
| Immunogen【免疫原】 | recombinant mouse IL-10 expressed in E. coli. |
| Application【应用】 | Anti-interleukin-10 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is suitable for neutralization reactions (ND50 is 2-4 μg/ml). |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
| Preparation Note【制备说明】 | Purified using protein G. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | goat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | mouse |
| technique(s) | neutralization: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | P18893 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Il10(16153) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
