Anti-GABA_A Receptor (β1 subunit), Cytosolic Loop antibody produced in rabbit

MFCD07370322

NA.41

GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes. GABAA receptor is a ligand-gated chloride channel that is a multimeric subunit complex. So far, around 16 subunits have been identified. This gene encodes the β1 subunit, which maps to human chromosome 4p12. It is present in a cluster along with genes encoding α 4, α 2 and γ 1 subunits of the GABA A receptor.

fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABA_A receptor (β1 subunit)

Anti-GABA_A Receptor (β1 subunit), Cytosolic Loop antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat membrane fraction.

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. Disruption in this receptor is implicated in autism. Alterations in N-glycosylation of α1, β1, and β2 have been observed in schizophrenic patients.

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous glycerol solution

sufficient for 10 blots

antigen apparent mol wt 51-54 kDa

rat

~0.2 mg/mL

western blot: 1:1,000 using rat membrane fraction

P15431

wet ice

−20℃

rat ... Gabrb1(25450)

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