您的位置：首页 > 产品中心 > Anti-FN3X (C-term) antibody produced in rabbit
Anti-FN3X (C-term) antibody produced in rabbit
| 产品编号： | 3362926 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-FN3X (C-term) antibody produced in rabbit
Anti-Fructosamine-3-kinase-related protein
Anti-Ketosamine-3-kinase
Anti-FN3KRP
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI accession no.【NCBI登记号】 | NP_078895 |
| UniProt accession no.【UniProt登记号】 | Q9HA64 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... FN3X(79672) |
基本信息
| General description【一般描述】 | Mammalian fructosamine-3-kinase (FN3K) catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines. FN3K for example catalyzes transformation of fructoselysine (FL) residues on glycated proteins, to FL-3-phosphate (FL3P). This phosphorylation destablilizes FL and propels spontaneous decomposition, thereby reversing at an early stage the nonenzymatic glycation process. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins. In mammals, FN3K has a closely related homologue, FN3KRP (FN3K-related protein), which in the human genome is located just 8 kb upstream of FN3K on chromosome 17q25.3 FN3KRP, which is 68% sequence identity with FN3K, is a deglycating enzyme which phosphorylates the third carbon of the sugar moiety of ketosamines, and may play a role in freeing proteins from ribulosamines or psicosamines. A deglycation system may be an important factor in protecting cells from the deleterious effects of nonenzymatic glycation, which appears to be an important factor in the pathogenesis of diabetic complications. |
| Immunogen【免疫原】 | FN3X (NP_078895, 284-319) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FN3X. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
