Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit

NA.41

Exportin 1/Crm1 (also known as XPO1, Exp1, chromosome region maintenance 1 protein homolog) is mapped to human chromosome 2p15.

Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Exportin 1/Crm1 has been implicated in various steps during mitosis.
Exportin-1 is a protein encoded by the XPO1 gene in humans. It is a novel cell-cycle regulated gene that is essential for the nuclear export signal-dependent nuclear export of proteins. XPO1 is highly expressed in mantle cell lymphoma (MCL) cells. It acts as selective inhibitor of nuclear export (SINE) compounds that induce apoptosis in MCL cells. XPO1 is expressed in subpopulation of Gastric cancer (GC) with aggressive behavior and can serve as a prognosis marker for poor outcome. It has helical hairpin HEAT repeats and a C-terminal helical extension (C-extension). The C-extension helps in regulating CRM1′s cargo-binding affinity by modulating the conformation and flexibility of its HEAT repeats.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~125 kDa

human

antibody small pack of 25 μL

~1.0 mg/mL

western blot: 2-4 μg/mL using K562 cell lysates

O14980

dry ice

−20℃

human ... XPO1(7514)
mouse ... Xpo1(103573)
rat ... Xpo1(85252)

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12 - Non Combustible Liquids

WGK 1