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Anti-EXOSC6 (AB2) antibody produced in rabbit

产品编号:3360845
规格:IgG fraction of antiserum
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3360845100 μL3310
产品别名

Anti-EXOSC6 (AB2) antibody produced in rabbit

Anti-Exosome component 6

基本信息
NACRES
NA.41
General description【一般描述】
Exosome complex (RNAse complex), a complex of 3′ -→ 5′ exoribonucleases, is a multi-protein complex that degrades various types of ribonucleic acids (RNA). Exosome component 6 (EAP4, MTR3, "Mtr3 (mRNA transport regulator 3)-homolog (yeast)") is a core exosome component that interacts with exosome components 1, 7 and 8 may be involved in exosome microtubule interaction.
Specificity【特异性】
Anti-EXOSC6 (AB2) polyclonal antibody reacts with canine, rat, mouse, human, and bovine Mtr3 (mRNA transport regulator 3)-homolog proteins.
Immunogen【免疫原】
Synthetic peptide directed towards the N terminal region of human EXOSC6
Application【应用】
Anti-EXOSC6 (AB2) polyclonal antibody is used to tag MTR3 protein for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the possible roles of MTR3 protein in the construction and function of specific exosomes.
Biochem/physiol Actions【生化/生理作用】
EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
Sequence【序列】
Synthetic peptide located within the following region: MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAK
Physical form【外形】
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
IgG fraction of antiserum
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
30 kDa
species reactivity
human
concentration【浓度】
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_478126
UniProt accession no.【UniProt登记号】
Q5RKV6
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... EXOSC6(118460)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
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