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Anti-ERCC8 (ab2) antibody produced in rabbit
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 44 kDa |
| species reactivity | human |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000073 |
| UniProt accession no.【UniProt登记号】 | Q13216 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ERCC8(1161) |
基本信息
| General description【一般描述】 | ERCC8 is a WD repeat protein that has been implicated in Cockayne syndrome. Cockayne syndrome is an autosomal recessive disorder that is characterized by mental retardation, photosensitivity, neurodegeneration and premature death. Rabbit Anti-ERCC8 recognizes canine, zebrafish, chicken, human, and mouse ERCC8. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the N terminal region of human ERCC8 |
| Application【应用】 | Rabbit Anti-ERCC8 can be used for western blot application at a concentration of 0.5μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. |
| Sequence【序列】 | Synthetic peptide located within the following region: DVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
