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Anti-EpCAM antibody, Mouse monoclonal

产品编号:3360180
规格:clone Ber-EP4, purified from hybridoma cell culture
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3360180100 μL6730
产品别名

Anti-EpCAM antibody, Mouse monoclonal

Anti-Major gastrointestinal tumor-associated protein GA733-2

Anti-EGP

Anti-KSA

Anti-Tumor-associated calcium signal transducer 1

Anti-Epithelial glycoprotein

Anti-Epithelial cell surface antigen

Anti-KS 1/4 antigen

Anti-CD326 antigen

基本信息
NACRES
NA.41
General description【一般描述】
The epithelial cell adhesion molecule (EpCAM) is mapped to human chromosome 2p21 and has nine exons. EpCAM is a 40 kDa transmembrane glycoprotein present on cell surface. It has an intracellular domain called the EpICD, comprising of 26-amino acids. The extracellular domain (EpEX) has an epidermal growth factor (EGF) and a thyroglobulin repeat-like domain.
Immunogen【免疫原】
human breast carcinoma cell line MCF-7
Biochem/physiol Actions【生化/生理作用】
The epithelial cell adhesion molecule (EpCAM) is highly expressed in carcinomas. It regulates cell signalling, proliferation, migration and adhesion. Proteolytic cleavage of EpICD domain is crucial for tumor progression. EpCAM is highly expressed in breast cancer and is considered as a potential target for gene therapy. Deletions in the 3′ region of the EpCAM gene is associated with colorectal cancer based lynch syndrome. Single nucleotide polymorphism in EpCAM gene is associated with infant diarrheal disorder, congenital tufting enteropathy(CTE).
Physical form【外形】
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
Ber-EP4, monoclonal
form【形式】
buffered aqueous solution
species reactivity
human
concentration【浓度】
~1 mg/mL
technique(s)
immunofluorescence: 1-2 μg/mL using human breast adenocarcinoma MCF-7 cell line.
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon carcinoma sections.
immunoprecipitation (IP): suitable
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
P16422
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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