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Anti-ELP3 (C-term) antibody produced in rabbit
| 产品编号： | 3359850 |
| 规格： | saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ELP3 (C-term) antibody produced in rabbit
Anti-HELP3
Anti-EC 2.3.1.48
Anti-ELP3
Anti-Elongator complex protein 3
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI accession no.【NCBI登记号】 | NP_060561 |
| UniProt accession no.【UniProt登记号】 | Q9H9T3 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ELP3(55140) |
基本信息
| General description【一般描述】 | The gene ELP3 (elongator complex protein 3) is mapped to human chromosome 8p21.1. The encoded protein has a HAT (histone acetyltransferase) domain. |
| Immunogen【免疫原】 | ELP3 (NP_060561, 473-508) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ELP3. |
| Biochem/physiol Actions【生化/生理作用】 | ELP3 (elongator complex protein 3) is a catalytic subunit of the histone acetyltransferase elongator complex. It enhances histone H3 acetylation, thereby regulating gene regulation in neurons. Dysregulation of ELP3 activity causes neuronal disorders, such as familial dysautonomia and amyotrophic lateral sclerosis. It might be a potential acetyltransferase for glucose-6-phosphate dehydrogenase. The ELP3 gene promoter is hypermethylated in invasive ductal breast carcinoma, causing transcriptional inactivation of the gene. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
