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Anti-EIF2AK2 (Ab-451) antibody produced in rabbit
产品别名
Anti-EIF2AK2 (Ab-451) antibody produced in rabbit
Anti-PKR antibody produced in rabbit
Anti-MGC126524 antibody produced in rabbit
Anti-PRKR antibody produced in rabbit
Anti-eukaryotic translation initiation factor 2-alpha kinase 2 antibody produced in rabbit
Anti-EIF2AK1 antibody produced in rabbit
基本信息
| MDL number | MFCD03455796 |
| NACRES | NA.41 |
| General description【一般描述】 | EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2α family of protein kinases. It contains two RNA binding domains and a kinase domain. It is located on chromosome 2p22-p21. |
| Immunogen【免疫原】 | Peptide sequence around aa. 449-453 (K-G-T-L-R), according to the protein EIF2AK2. |
| Biochem/physiol Actions【生化/生理作用】 | EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferon. It is involved in stress response and inflammation pathways. It controls the development and multiplication of cell, nutrient signaling and metabolism. It also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~74 kDa |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (K-G-T-L-R) |
| NCBI accession no.【NCBI登记号】 | NP_001129123.1 |
| UniProt accession no.【UniProt登记号】 | P19525 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... EIF2AK2(5610) |
产品说明
| Target description【目标描述】 | Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
