Anti-Coronin 1B antibody produced in rabbit

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~66 kDa

rat, mouse, human

antibody small pack of 25 μL

~1.5 mg/mL

indirect immunofluorescence: 5-10 μg/mL using HS68 cells
western blot: 1.5-3.0 μg/mL using PC12 cell extracts and mouse brain extracts (S1 fraction)

Q9BR76

dry ice

−20℃

human ... CORO1B(57175)

Coronin 1B (CORO1B) is encoded by the gene mapped to human chromosome 11q13.2. CORO1B belongs to the mammalian coronin gene family. The encoded protein is ubiquitously expressed and is mainly present on the leading edge of migrating fibroblasts.
Coronin-1B localizes to sub-membrane areas.

Anti-Coronin 1B antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Coronin-1B has been shown to affect cell motility by regulation of actin-depolymerizing factor (ADF)/cofilin proteins at the leading edge. It targets the cofilin-activating phosphatase slingshot-1L to the leading edge, and thus indirectly regulates cofilin activity.
Coronin 1B (CORO1B) acts as an actin binding protein. It also plays a major role in controlling whole-cell motility and lamellipodial dynamics. CORO1B also influence neurite outgrowth in a neuronal regeneration model. The encoded protein antagonizes a filament branch stabilizer, cortactin and disassembles actin-related protein (Arp) 2/3-containing actin filament branches by promoting Arp2/3 dissociation.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids