Anti-COG6 (C-terminal) antibody produced in rabbit

NA.41

Conserved Oligomeric Golgi complex 6 (COG6), also known as COD2, is a member of the conserved oligomeric Golgi (COG) complex. COG complex is composed of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3- Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.

a peptide corresponding to the C-terminal region of human COG6, conjugated to KLH. The corresponding sequence differs by three amino acids in mouse and rat COG6.

Anti-COG6 (C-terminal) antibody produced in rabbit has been used in various immunochemical techniques including immunoblotting and immunoprecipitation.

COG complex is an evolutionarily conserved multi-subunit protein complex that regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. COG complex interacts directly with the target membrane (t-SNARE) Syntaxin 6 through COG6 subunit. COG6-depleted cells display reduced steady-state level of Syntaxin 6 and attenuated endosome-to- trans‐Golgi network (TGN) retrograde trafficking. Deficiency of COG6 causes a combined N- and Oglycosylation deficiency of the congenital disorders of glycosylation, designated as CDG-IIL (COG6- congenital disorders of glycosylation (CDG)).

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~70 kDa

human

~1.0 mg/mL

immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells
western blot: 2-4 μg/mL using whole extracts of human HEK-293T cells

Q9Y2V7

dry ice

−20℃

human ... COG6(57511)

12 - Non Combustible Liquids