Anti-Cdk1 (p34^cdc2) antibody produced in rabbit

MFCD00239719

NA.41

The gene Cyclin-dependent kinase 1 (CDK1) is mapped to human chromosome 10q21.1. The protein localizes in the cytoplasm and the nucleus. CDK1 is also popularly called as CDC2.

synthetic peptide corresponding to amino acids 263-287 of the C-terminus of mouse cdk1/cdc2.

Anti-Cdk1 (p34cdc2) antibody produced in rabbit is suitable for immunoprecipitation and western blot (chemiluminescent) at a dilution of 1:500-1:2,000 using mouse 3T3 cell lysates.

Cyclin-dependent kinase 1 (CDK1) plays a vital role in the control of eukaryotic cell cycle by modulating the centrosome cycle and the onset of mitosis. It promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. It is essential for development of early embryonic stage. The antibody may cross-react with other cdc2-like kinase. CDK1 is a component of M-phase promoting factor. CDK1 interacts with FAC (Fanconi anemia group C protein) and the binding is important for normal G2/M progression. Similarly, Cep63 binds and recruits Cdk1 to centrosomes, thereby regulating mitotic entry. CDK2 also foms a complex with cyclin E, cyclin A and cyclin D.

rabbit

200

unconjugated

whole antiserum

primary antibodies

polyclonal

antigen 34 kDa

0.05% sodium azide as preservative

human (predicted), rat (predicted), mouse

immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:500-1:2,000 using mouse 3T3 cell lysates

dry ice

−20℃

human ... CDC2(983)
mouse ... Cdc2a(12534)
rat ... Cdc2(54237)

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WGK 3

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