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Anti-C17ORF71 antibody produced in rabbit
产品别名
Anti-C17ORF71 antibody produced in rabbit
Anti-FLJ10587
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The gene SMG8 (nonsense mediated mRNA decay factor) is mapped to human chromosome 17q22. It is a part of the SMG-1 kinase (phosphatidylinositol 3-kinase-related kinase) complex. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the middle region of human C17orf71 |
| Biochem/physiol Actions【生化/生理作用】 | SMG8 (nonsense mediated mRNA decay factor) helps in bringing the inactive SMG-1 (phosphatidylinositol 3-kinase-related kinase) to the SURF (SMG-1-Upf1-eRF1-eRF3) complex. Knockdown of the SMG8 gene suppresses nonsense-mediated mRNA decay without cytotoxic effects. Loss of function of SMG8 causes accumulation of ribosome:Upf1 (up-frameshift suppressor 1 homolog):eRF1 (eukaryotic translation termination factor 1):eRF3:EJC (exon junction complex) complex on mRNP (messenger ribonucleoprotein), connecting the ribosome and EJC. |
| Sequence【序列】 | Synthetic peptide located within the following region: HCVHKFHSLPKSGEKPEADRNPPVLYHNSRARSTGACNCGRKQAPRDDPF |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 110 kDa |
| species reactivity | mouse, horse, rabbit, dog, rat, guinea pig, human, bovine |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NM_018149 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... C17orf71(55181) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
