Anti-AR (Ab-650) antibody produced in rabbit

NA.41

Peptide sequence around aa. 648-652 (T-T-S-P-T), according to the protein AR.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~110 kDa

human, mouse

1 mg/mL

western blot: 1:500-1:1000

IgG

(T-T-S-P-T)

NP_000035.2

P10275

wet ice

−20℃

human ... AR(367)

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

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10 - Combustible liquids

WGK 1